Vice President Clinical Development Immunology

Job Title: Vice President, Clinical Development - Immunology

Location: Cambridge, MA or Oakland, CA (Hybrid)

Hiring Manager: Chief Scientific Officer

Position Summary: We are seeking a Vice President, Clinical Development – Immunology, to lead and oversee the execution of early-phase immunology clinical programs across our portfolio companies. The role requires a physician-scientist with deep expertise in early-stage drug development, a track record of running clinical trials, and the ability to lead cross-functional teams and external partners. The successful candidate will be a key driver of our immunology portfolio strategy, ensuring timely, compliant, and high-quality execution of clinical studies.

Responsibilities:

· Lead execution of Phase 1 and Phase 2 clinical trials within assigned portfolio companies.

· Collaborate with the CSO, Immunology, and Clinical Operations leadership to design and implement clinical development plans aligned with overall product strategy.

· Oversee safety monitoring, adverse event assessment, and go/no-go decisions for clinical programs.

· Provide ongoing medical monitoring for active trials, including review of protocol deviations and screening failures.

· Serve as primary medical liaison for investigators and CRO partners, offering medical guidance and training site staff on protocol requirements.

· Maintain deep scientific knowledge of disease pathways by reviewing literature, attending medical congresses, and engaging with KOLs.

· Drive cross-functional collaboration across regulatory, operations, and external partners to ensure program milestones are achieved.

Required Qualifications:

· MD or MD/PhD with at least 6 years of industry experience in clinical development at a pharmaceutical or biotech company.

· Demonstrated expertise in early-stage development (pre-IND, IND, Phase 1 and Phase 2).

· Proven ability to independently run clinical programs with minimal oversight.

· Strong background in immunology clinical programs (highly preferred).

· Extensive knowledge of clinical trial design, methodology, regulatory requirements, and compliance.

· Leadership experience in a matrixed environment with strong vendor management capabilities.

· Excellent communication and collaboration skills.

Preferred Qualifications:

· Prior experience advancing novel immunology therapeutics through early proof-of-concept.

· Established relationships with leading immunology investigators and KOLs.

· Experience in translational and biomarker-driven trial design.

Compensation: $395,000 – $440,000 base salary, plus target bonus, equity participation, and comprehensive benefits (medical, dental, vision, 401k). Final package will be determined based on experience, skills, and education.